Does CD34 positive mean cancer?
Does CD34 positive mean cancer?
The unique clinicopathological features of superficial CD34-positive fibroblastic tumor define them as a novel subset of low-grade fibroblastic neoplasms, best considered to be of borderline malignancy.
Is spindle cell neoplasm a cancer?
Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. It can arise in any part of the body but is most common in the limbs (arms and legs).
What does CD34 stain for?
CD34 is 115 kDa membrane associated antigen found on human hematopoietic progenitor cells and vascular endothelial cells. In normal tonsil sections, antibodies to CD34 strongly stain vascular endothelial cells. CD34 is used as a marker of immaturity in the setting of acute myeloid leukemia or B lymphoblastic leukemia.
Can a spindle cell tumor be benign?
The name ‘spindle cell’ refers to the shape of the cell on cytology and histology. Spindle cell tumours can be benign (suffix -oma) or malignant (suffix -sarcoma), and will arise from these different cell lines.
What is Dermatofibrosarcoma?
Dermatofibrosarcoma protuberans (DFSP) is a very rare type of skin cancer that begins in connective tissue cells in the middle layer of your skin (dermis). Dermatofibrosarcoma protuberans may at first appear as a bruise or scar. As it grows, lumps of tissue (protuberans) may form near the surface of the skin.
What is spindle cell neoplasm?
Spindle cell neoplasms are defined as neoplasms that consist of spindle-shaped cells in the histopathology. Spindle cell neoplasms can affect the oral cavity. In the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components.
Is spindle cell cancer aggressive?
Cutaneous spindle cell squamous cell carcinoma (SpSCC) is a rare and often aggressive subtype of squamous cell carcinoma (SCC), which usually appears in sun-exposed areas, in areas that have received prior ionizing radiation, or in immunosuppressed individuals.
Is neoplasm the same as cancer?
An abnormal mass of tissue that forms when cells grow and divide more than they should or do not die when they should. Neoplasms may be benign (not cancer) or malignant (cancer).
What is a normal CD34 count?
Under normal conditions, CD34+ cells in PB range from 0.01 to 0.05%5; in the BM, the concentration is usually less than 1% of normal mononuclear cells.5, 6, 7, 8 The number of progenitor cells to be infused to reach a proper hematopoietic recovery is still controversial,9, 10 however a minimum of 2–5 × 106 CD34+ cells/ …
What is a CD34 cell?
CD34 is a 115-kDa transmembrane glycoprotein expressed on the surface of hematopoietic progenitor cells and small blood vessel endothelial cells. While the specific function of CD34 remains to be elucidated, it is regarded as a marker of hematopoietic stem cells (HSC) and hematopoietic progenitor cells.
What is the survival rate for spindle cell sarcoma?
The relative 5-year survival rates were 84% for those aged 20 to 49 years and 48% for those 50 to 69 years. Those older than 70 years had a 2-year relative survival rate of only 30%.
Can spindle cell sarcoma be cured?
A sarcoma is considered stage IV when it has spread to distant parts of the body. Stage IV sarcomas are rarely curable. But some patients may be cured if the main (primary) tumor and all of the areas of cancer spread (metastases) can be removed by surgery. The best success rate is when it has spread only to the lungs.
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