How does estrogen affect the epiphyseal plate?

09/12/2020 Off By admin

How does estrogen affect the epiphyseal plate?

First, estrogen reversibly suppresses growth plate function, including proliferation in the proliferative zone, hypertrophic cell size, and consequently the rate of longitudinal bone growth. Second, estrogen irreversibly advances structural senescence of the growth plate and hastens epiphyseal fusion.

Which hormone is responsible for epiphyseal fusion?

Estrogens are known to play a key role in longitudinal bone growth by stimulating growth plate maturation, epiphyseal fusion and bone mineral accrual.

Does estrogen fuse growth plates?

In some mammals, including humans, the growth plate is resorbed at the time of sexual maturation. This process, epiphyseal fusion, terminates longitudinal bone growth. Estrogen is pivotal for epiphyseal fusion in both young men and women (10). The mechanism by which estrogen promotes epiphyseal fusion is not known.

What hormone closes epiphyseal plate?

Estrogen and testosterone release at puberty initiates closure of the epiphyseal plates. When bone growth is complete, the epiphyseal cartilage is replaced with bone, which joins it to the diaphysis.

Does estrogen stop growth?

It is the high concentration of estrogen in the blood that causes the growth plates of our bones to fuse. This fusion effectively closes the growth centers of long bones and renders them unable to respond to the hormones that initiate growth.

What does estrogen do to growth?

Estrogen plays a key role in the regulation of growth in both genders, via its stimulation of the pubertal growth spurt and mediation of epiphyseal fusion.

Does estrogen cause growth?

Does estrogen make U taller?

The study showed that girls who started using the low dose estrogen at the average age of nine and who also used growth hormone grew an average of 3 inches taller than girls who didn’t use growth hormone, or girls treated with only low dose estrogen.

What happens when you have no estrogen?

Low estrogen levels can interfere with sexual development and sexual functions. They can also increase your risk for obesity, osteoporosis, and cardiovascular disease. Treatments have evolved over the years and become more effective.

Does estrogen stop height?

“Estrogen was thought to reduce height by 1 to 2 inches. Growth hormone is thought to increase height by 1 to 2 inches.” In slow-growing children, the medical term is idiopathic short stature. In rapidly growing children, the term is constitutional tall stature.