What does repertoire mean in immunology?
What does repertoire mean in immunology?
Immune repertoire refers to all of the unique T-cell receptor (TCR) and B-cell receptor (BCR) genetic rearrangements within the adaptive immune system. Researchers also refer to the TCR repertoire and BCR repertoire when studying T cells and B cells, respectively.
What is genetic repertoire?
Such a gene repertoire can be defined by several criteria: number of genes, types/classes of genes, variability among genes, and the diversity created. Thus, greater resolution (denser contours, more genes) may not necessarily mean greater variability or diversity.
What is B cell repertoire?
B cells are important in the pathogenesis of many, and perhaps all, immune-mediated diseases. Each B cell expresses a single B cell receptor (BCR)1, and the diverse range of BCRs expressed by the total B cell population of an individual is termed the ‘BCR repertoire’.
What is a repertoire system?
The immune repertoire encompasses the different sub-types an organism’s immune system makes of immunoglobulins or T-cell receptors. These help recognise pathogens in most vertebrates. Such a wide variety increases the odds of having a sub-type that recognises one of the many pathogens an organism may encounter.
What does repertoire mean in medical terms?
A reference book which lists homeopathic symptoms and the remedies used to treat them. Because the details on the modalities, locations and sensations associated with the symptoms may be exhaustive, repertories are typically very large.
Do paralogs always have the same function?
Paralogs typically have the same or similar function, but sometimes do not. Due to lack of the original selective pressure upon one copy of the duplicated gene, this copy is free to mutate and acquire new functions.
Which type of prokaryote typically has the smallest genome?
The smallest Bacterial genome identified thus far is from Mycoplasma genitalium, an obligate intracellular pathogen with a genome size of 0.58 Mbp (580 Kbp).
What is a B cell Clonotype?
A clonotype is defined as a group of antibody sequences which derive from a common progenitor B cell . During B cell development, the variable (V), diversity (D) and joining (J) gene segments encoding the variable domain of the antibody heavy chain undergo recombination .
What are B cells?
B cells are a type of lymphocyte that are responsible for the humoral immunity component of the adaptive immune system. These white blood cells produce antibodies, which play a key part in immunity. Each B cell contains a single round nucleus.
What is immune sequencing?
Immune repertoire sequencing (Immuno-Seq) targets at T/B lymphocytes and utilizes the 5′ Rapid Amplification of cDNA Ends (RACE) Technology. The 5′ RACE technology amplifies complementarity-determining regions (CDRs) of B cell receptors (BCRs) or T cell receptors (TCRs).
What is the definition of repertoire for kids?
Kids Definition of repertoire. : a list or supply of plays, operas, or pieces that a company or person is prepared to perform. Keep scrolling for more.
What do you mean by repertories in medical dictionary?
A reference book which lists homeopathic symptoms and the remedies used to treat them. Because the details on the modalities, locations and sensations associated with the symptoms may be exhaustive, repertories are typically very large. Segen’s Medical Dictionary. © 2012 Farlex, Inc.
How is the repertoire of the immune system generated?
How is the immune repertoire generated. The repertoire is generated, by immune system cells (lymphocytes) cutting a bit of DNA from 2 or 3 parts of the genome, and joining them together in different combinations. Each part of the genome, has only a few different pieces of DNA that can be used.
What does repertoire mean in West Side Story?
He just sort of takes in the entire repertoire of a person: their voice, gestures, movements, idiosyncrasies, habits. Their repertoire apparently knows no limits, nor does their energy onstage. They also played “Freebird,” a song not typically included in their repertoire. Occasionally, her repertoire includes songs from “West Side Story.”