What happens when bone deposition is greater than resorption?

08/10/2019 Off By admin

What happens when bone deposition is greater than resorption?

In adults, the daily removal of small amounts of bone mineral, a process called resorption, is balanced by an equal deposition of new mineral in order to maintain bone strength. When this balance tips toward excessive resorption, bones weaken and over time can become brittle and prone to fracture (osteoporosis).

What happens during bone deposition?

Osteoblasts secrete osteoid (a composite of collagen, chondroitin sulfate, and osteocalcin). Hydroxyapatite crystals are deposited into the bone matrix. Calcification of bone occurs when calcium and phosphate ions move out of the blood into the bone tissues.

What is bone deposition vs resorption?

Bone remodeling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous matrix. Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification.

What happens during bone remodeling?

The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently become mineralized.

Does vitamin D increase bone resorption?

Previous studies have shown that high doses of vitamin D did result in increased resorption of bone unless calcium was also supplemented. The active form of vitamin D called calcitriol increases the production of osteoclasts which enhance bone resorption.

How long does bone resorption take?

The healing process takes approximately 12 to 16 weeks. According to Schropp et al., about two-thirds of the affected hard and soft tissues undergo some degree of resorption change during the first three months after the extraction [3].

How does vitamin D cause bone resorption?

Do bone cells get replaced?

Bone Remodeling The body’s skeleton forms and grows to its adult size in a process called modeling. It then completely regenerates — or remodels — itself about every 10 years. This keeps the bone and its cells healthy and strong and allows the bones to supply calcium to the body.

What diseases increase bone resorption?

Clinical disorders in which bone resorption is increased are very common and include Paget’s disease of bone, osteoporosis, and the bone changes secondary to cancer, such as occur in myeloma and metastases from breast cancer.

Why is bone resorption bad?

This is a natural process that’s important for your health and wellbeing. But when resorption happens at a higher rate than it can be replaced, it can lead to a decrease in your bone mass and put you at higher risk for fractures and breakage. In your mouth, your jawbone is most likely to be affected by this phenomenon.