What is AMACR pathology outlines?

09/10/2019 Off By admin

What is AMACR pathology outlines?

Alpha methyacyl CoA racemase (AMACR) is a mitochondrial and peroxisomal enzyme, a 382 amino acid protein essential in lipid metabolism, encoded by a 1621 bp sequence gene, located on chromosome 5p13 (J Clin Pathol 2003;56:892)

What is PIN4?

PIN4 consists of a cocktail of three antibodies, including AMACR(P504S), p63, and high molecular weight cytokeratin.

What does intraepithelial neoplasia mean?

Listen to pronunciation. (IN-truh-eh-pih-THEE-lee-ul NEE-oh-PLAY-zhuh) A condition in which abnormal cells are found on the surface of or in the tissue that lines an organ, such as the prostate, breast, or cervix.

Is high-grade intraepithelial neoplasia cancerous?

“High-grade PIN is considered a pre-cancer of the prostate because it may turn into prostate cancer over time,” the society said. “In most cases, high-grade prostatic intraepithelial neoplasia will not turn into cancer over the next several years.

What is the pathology of alpha methylacyl CoA racemase?

Alpha-methylacyl-CoA racemase Synonyms racemase Subspeciality genitourinary pathology Normal staining pattern cytoplasmic Positive prostate carcinoma ~90%, high grade pros

How is racemase used in the treatment of cancer?

Racemase (α-methylacyl-coenzyme A [CoA] racemase [AMACR] or P504S) is invaluable for separating benign and neoplastic acini, including evaluation of PIN, ASAP, and separation of cancer from hormonally treated benign acini.

Can a positive racemase stain be used to diagnose cancer?

Positive racemase staining converts an atypical diagnosis, based on suspicious histology and negative basal cell marker stains, to cancer in approximately 10% of cases thought to be atypical by contributing pathologists, and in approximately 50% of cases thought to be atypical by a specialist in genitourinary pathology.

What kind of staining is found on racemase?

Compare with (B), immunostain of high-grade PIN reveals both red cytoplasmic granular staining pattern of racemase and dark brown cytoplasmic (34βE12) and nuclear (p63) staining of basal cells. (C) H&E of adenocarcinoma (Gleason 3 + 3 = 6) on biopsy with adjacent benign acini.