What is Ashwagandha withanolides?

What is Ashwagandha withanolides?

What are withanolides? Withanolides are the active ingredient in ashwagandha, a popular adaptogen sold in supplement form. Ashwagandha’s benefits work best when it includes a high concentration of withanolides, which research shows can be beneficial in inhibiting tumor growth and fighting inflammation.

Are withanolides alkaloids?

Withanolides are structurally distinct from tropane/nortropane alkaloids (usually found in Solanaceae plants) and are produced only by a few genera within Solanaceae. W. somnifera contains many structurally diverse withanolides in its leaves as well as roots.

What are the benefits of withanolides?

Withanolides are the active compound of Ashwagandha, with multiple benefits and plenty of uses due to their antioxidant, anti-inflammatory and hormone balancing properties. Hence, Ashwagandha is also called an adaptogen and its uses include anti-ageing, boosting immunity, benefits for insomnia and joint pain, etc.

How does Withaferin a work?

Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis 2011; 32: 1697–1705.

Is ashwagandha safe for long term use?

When taken by mouth: Ashwagandha is possibly safe when used for up to 3 months. The long-term safety of ashwagandha is not known. Large doses of ashwagandha might cause stomach upset, diarrhea, and vomiting. Rarely, liver problems might occur.

What type of ashwagandha is best?

Best Ashwagandha Extracts. When it comes to quality and efficacy, two branded ashwagandha extracts stand far above the rest: KSM-66 and Sensoril. These are both standardized, high potency, full-spectrum, certified organic extracts with a long list of verified health benefits backed by clinical studies.

Is Withaferin a safe?

5. Conclusion. Our phase I study found that oral Withaferin-A in patients with advanced stage, high grade osteosarcoma has a good safety profile. Further phase II studies of WA can be conducted at a dose of 216 mg/day.

What are steroidal lactones?

Withanolides are a group of at least 300 naturally occurring steroids built on an ergostane skeleton. Structurally, withanolides consist of a steroid backbone bound to a lactone or one of its derivatives; they are produced via oxidation of steroids.