What is Coumadin toxicity?

What is Coumadin toxicity?

Warfarin toxicity happens when you have too much warfarin in your body. Certain changes to foods and medicines can also increase the effect of warfarin. Warfarin is a medicine that is used to prevent or treat the formation of blot clots. It works by making your blood clot more slowly.

What is the antidote of warfarin?

Vitamin K (phytonadione) Kcentra. FFP (fresh frozen plasma)

What is a therapeutic INR level?

In healthy people an INR of 1.1 or below is considered normal. An INR range of 2.0 to 3.0 is generally an effective therapeutic range for people taking warfarin for disorders such as atrial fibrillation or a blood clot in the leg or lung.

What causes INR increase?

Vitamin K deficiency: Malnutrition, prolonged use of broad-spectrum antibiotics and fat malabsorption syndrome can prolong the PT/INR. DIC: Prolonged PT/INR results from the consumption of the coagulation factor in the clotting process.

What happens when Coumadin levels are too high?

A value higher than 3.5 increases the risk of bleeding problems. Many things can affect the way warfarin works. Some natural health products and other medicines can make warfarin work too well. That can raise the risk of bleeding.

Does warfarin damage the liver?

Hepatotoxicity. Liver injury due to warfarin therapy is rare, but clinically apparent acute liver injury attributable to it has been reported. Liver injury is more common with other coumarin derivatives such as phenprocoumon and acenocoumarol, which are available in other countries but not in the United States.

When to treat warfarin and supratherapeutic INR?

Warfarin and supratherapeutic INR, Should we treat it? In patients on warfarin presenting to the ED with asymptomatic supratherapeutic INR greater than 3.5, is treatment with vitamin K compare to no treatment with vitamin K associated with worse outcomes defined as increased risk of major bleeding?

Is it safe to take botanicals with Coumadin?

Exercise caution when botanical (herbal) products are taken concomitantly with COUMADIN. Few adequate, well-controlled studies evaluating the potential for metabolic and/or pharmacologic interactions between botanicals and COUMADIN exist.

Is there a risk of bleeding from supratherapeutic INR?

There is low risk of bleeding in patients with supratherapeutic INR. Outpatient management is recommended, but close follow up is key. There should be an emphasis on not creating warfarin resistance or making the patient subtherapeutic. Vitamin K should be used in those with INR>5 and increased risk of bleeding.

What does supratherapeutic INR mean in medical terms?

What exactly is supratherapeutic INR? I’ve done some research but didn’t get a clear answer. From my understanding, supratherpeutic INR means that a patient who is on warfarin or an anticoagulant has maintained a level of the drug above the therapeutic level. Can someone clarify or add to this?