What is DFS and PFS?
What is DFS and PFS?
Disease-Free Survival (DFS), also known as Relapse-Free Survival (RFS), is often used as a primary endpoint in phase III trials of adjuvant therapy. ◆ Progression-Free Survival (PFS) is used commonly as a primary endpoint in phase III trials evaluating treatment of metastatic cancer.
What does RFS mean with cancer?
In cancer, the length of time after primary treatment for a cancer ends that the patient survives without any signs or symptoms of that cancer. In a clinical trial, measuring the RFS is one way to see how well a new treatment works. Also called DFS, disease-free survival, and relapse-free survival.
What is IDFS in breast cancer?
Invasive disease-free survival (IDFS), defined as occurrence of any of the following: ipsilateral invasive breast cancer recurrence, regional invasive breast cancer recurrence, distant recurrence, death attributable to any cause, contralateral invasive breast cancer, or second non-breast invasive cancer.
What is EFS in clinical trial?
The measure of time after treatment that a group of people in a clinical trial has not had cancer come back or get worse. This term is also usually used in the context of scientific research.
What is the difference between OS and PFS?
Progression-free survival (PFS), the time from treatment initiation until disease progression or worsening, may be used as a direct or surrogate measure of clinical benefit for drug approvals, depending on the disease and response observed, while overall survival (OS), the duration of patient survival from the time of …
What is the difference between relapse and progression?
Progression is when cancer spreads or gets worse. Sometimes it is hard to tell the difference between recurrence and progression. There is no standard period of time within the definition of recurrence, but most doctors consider a cancer to be a recurrence if you had no signs of cancer for at least a year.
What is considered distant metastasis?
Listen to pronunciation. (DIS-tunt meh-TAS-tuh-sis) Refers to cancer that has spread from the original (primary) tumor to distant organs or distant lymph nodes. Also called distant cancer.
What is the difference between EFS and DFS?
EFS is used in the neoadjuvant setting to imply time from randomization to disease relapse, recurrence, progression or death (the only difference between EFS and DFS is that EFS is in the neoadjuvant setting while DFS is in the adjuvant setting) . In past trials in the adjuvant setting, EFS was used to mean DFS.
What does event-free mean?
Being event-free can mean that the cancer being treated does not recur. It could mean that there is no bone pain from cancer that has spread to the bone. A higher percentage of patients remaining event-free shows that a treatment is more effective.