What is digoxin used for?

06/22/2020 Off By admin

What is digoxin used for?

Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It helps the heart work better and it helps control your heart rate.

What is the mechanism of action of digoxin?

Mechanism of Action Digoxin induces an increase in intracellular sodium that will drive an influx of calcium in the heart and cause an increase in contractility. Cardiac output increases with a subsequent decrease in ventricular filling pressures. [2] AV Node Inhibition: Digoxin has vagomimetic effects on the AV node.

What is digoxin metabolized by?


Clinical data
Protein binding 25%
Metabolism Liver (16%)
Elimination half-life 36 to 48 hours (normal kidney function) 3.5 to 5 days (impaired kidney function)
Excretion Kidney

What medication is used to treat digoxin toxicity?

The primary treatment of digoxin toxicity is digoxin immune fab, which is an antibody made up of anti-digoxin immunoglobulin fragments. This antidote has been shown to be highly effective in treating life-threatening signs of digoxin toxicity such as hyperkalemia, hemodynamic instability, and arrhythmias.

What kind of glycosides are in Digoxin Tablets?

PRESCRIBING INFORMATION Lanoxin (digoxin) Tablets, USP 125 mcg (0.125 mg) Scored I.D. Imprint Y3B (yellow) 250 mcg (0.25 mg) Scored I.D. Lanoxin (digoxin) is one of the cardiac (or digitalis) glycosides, a closely related group of drugs having in common specific effects on the myocardium. These drugs are found in a number of plants.

When to tell your doctor about digoxin side effects?

Before taking digoxin, Older adults should usually receive low doses of digoxin because higher doses may cause serious side effects. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking digoxin. you should know that this medication may make you drowsy.

Is the aglycone digoxin positive or negative?

Digoxin is a cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity.

How much digoxin is in a Lanoxin tablet?

Lanoxin is supplied as 125-mcg (0.125-mg) or 250-mcg (0.25-mg) tablets for oral. administration. Each tablet contains the labeled amount of digoxin USP and the following. inactive ingredients: corn and potato starches, lactose, and magnesium stearate.