What is primary refractory lymphoma?

11/17/2019 Off By admin

What is primary refractory lymphoma?

Primary refractory disease was defined as a failure to achieve a CR with a front-line regimen containing rituximab and an anthracycline.

What is primary refractory?

Definition. Disease status just prior to the start of the preparative regimen for hematopoietic stem cell transplantation (HSCT): Primary refractory refers to never achieving a complete remission (CR) from any therapy and also not being in partial remission (PR) at the time of the last evaluation prior to HSCT.

What does refractory lymphoma mean?

The term “refractory” is used to describe when the lymphoma does not respond to treatment (meaning that the cancer cells continue to grow) or when the response to treatment does not last very long.

Can refractory lymphoma be cured?

The prognosis for these patients is poor, especially for those who have high-risk factors such as secondary IPI score >2 or relapse ≤12 months post-ASCT. Thus, most patients with refractory DLBCL have no curative treatment options.

What is primary refractory AML?

Abstract. Between 10% and 40% of newly diagnosed patients with acute myeloid leukemia (AML) do not achieve complete remission with intensive induction therapy and are therefore categorized as primary refractory or resistant. Few of these patients can be cured with conventional salvage therapy.

What is the difference between relapse and refractory?

Relapsed disease means a cancer has come back. Refractory disease means a cancer has stopped responding to treatment.

How bad is chemo for lymphoma?

Chemotherapy kills cells that multiply quickly, such as lymphoma cells. It also causes damage to fast-growing normal cells, including hair cells and cells that make up the tissues in your mouth, gut and bone marrow. The side effects of chemotherapy occur as a result of this damage.

Which lymphoma has the highest survival rate?

The 5-year survival rate for all people with Hodgkin lymphoma is 87%. If the cancer is found in its earliest stages, the 5-year survival rate is 91%. If the cancer spreads regionally, the 5-year survival rate is 94%.

What is refractory disease?

(reh-FRAK-tor-ee) In medicine, describes a disease or condition that does not respond to treatment.

What is the recurrence rate of lymphoma?

Although the majority of patients with classical Hodgkin lymphoma (cHL) are cured in the modern treatment era, up to 30%1,2 with advanced-stage and 5% to 10%3-6 with limited-stage disease experience relapse.

What are good treatments for B-cell lymphoma?

Some aggressive B-cell lymphomas can be cured with chemotherapy , especially in early stage disease. DLBCL is a fast-growing type that can be treated with a chemotherapy regimen called CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone).

How do I treat follicular lymphoma?

The treatments of follicular lymphoma always include: Radiation therapy: Use high-energy beams like X-rays to kill cancer cells. Monoclonal antibodies: For example, rituximab (Rituxan) works well to kill lymphoma cells with fewer side effects.

What is the treatment for lymphatic cancer?

Treatment for lymphatic cancer can include surgery, radiation therapy and chemotherapy amongst other things. Treatment is slow and can be extremely hard on the body, so using a natural cure to help treat pain at home can be of great use.

How is follicular lymphoma treated?

Follicular lymphoma can be treated by stem cell transplantation, which involves transferring healthy stem cells that give rise to lymphocytes, either from the patient’s body or from a donor. This approach results in a healthy blood-forming system, producing healthy red blood cells, white blood cells, and platelets.