What is Thrombin-JMI?
What is Thrombin-JMI?
THROMBIN-JMI is a topical thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical. (
How much does thrombin cost?
The cost for Thrombin-JMI topical powder for reconstitution (bovine 20,000 intl units) is around $306 for a supply of 1 powder for reconstitution, depending on the pharmacy you visit….Topical Powder For Reconstitution.
| Quantity | Per unit | Price |
|---|---|---|
| 1 | $306.47 – $321.33 | $306.47 – $321.33 |
Who makes thrombin?
Pfizer
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How do you mix thrombin?
Reconstitution
- For routine use, reconstitute THROMBIN-JMI with sterile isotonic saline at a recommended concentration of 1,000 to 2,000 International Units per mL.
- Where bleeding is profuse, as from abraded surfaces of liver or spleen, concentrations of 1,000 International Units per mL may be required.
Is thrombin a drug?
[1] Bovine thrombin was the first thrombin product approved by the US Federal Drug Administration (FDA) as an ancillary aid for topical hemostasis during surgical procedures in 1943.
What is thrombin used for in surgery?
There are many ways thrombin is used during a surgical procedure to effect hemostasis. It can be used alone, in combination with an absorbable hemostatic carrier, or in a manufactured combination with fibrin.
What is thrombin used for?
Thrombin is a topical hemostatic agent used to control and minimize blood loss during surgical procedures, is utilized in conjunction or as an alternative to standard surgical techniques.
Is thrombin a blood product?
Thrombin can be prepared from blood plasma. The preparation involves three main steps: isolation of prothrombin from plasma, activation to thrombin, and purification of the mature enzyme from the activation mixture. Thrombin can then be purified from other activation components by cation-exchange chromatography [2,5].
How do you store thrombin?
Lyophilized Thrombin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thrmbin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
What drug category is thrombin?
Thrombin inhibitors are anticoagulants that bind to and inhibit the activity of thrombin therefore prevent blood clot formation. Thrombin inhibitors inactivate free thrombin and also the thrombin that is bound to fibrin. Thrombin inhibitors are used to prevent arterial and venous thrombosis.
Where is thrombin found in the body?
The thrombin (prothrombin) gene is located on the eleventh chromosome (11p11-q12).